The S&P 500 financial index slipped 0.48 percent, weighed down by Berkshire Hathaway and JPMorgan. The sector had risen more than 1 percent a day earlier.
MSCI's broadest index of Asia-Pacific shares outside Japan was 0.2 percent higher in early trade, pushing against its loftiest levels since June 2015.
The S&P 500's best day in nearly two weeks came after a record-setting rally for stocks in the wake of President Donald Trump's election in November had stalled this month.
MSCI's broadest index of Asia-Pacific shares outside Japan edged up 0.2 percent and back toward recent 21-month peaks.
Asian stocks crawled higher in early trade on Friday, set for its best week since September.
The S&P 500 consumer discretionary index lost 0.44 percent, with TripAdvisor sinking 10.97 percent after posting lower-than-expected quarterly revenue and profit.
Fundamentals also remain robust. A spate of strong economic data in recent weeks has run parallel with upbeat corporate results.
MSCI's broadest index of Asia-Pacific shares outside Japan inched up 0.3 percent, with Australia ahead by 0.1 percent.
U.S. equities had hit a series of record highs following Trump's election in November, encouraged by his promise of tax cuts and simpler regulations.
The dollar was down 0.1 percent at 113.670 yen after dropping more than 1 percent overnight, when it was knocked off its perch above 115.000.
MSCI's broadest index of Asia-Pacific shares outside Japan fell 0.3 percent while Japan's Nikkei dropped 1.1 percent.
On the sectoral front, buying was seen in heavyweight capital goods, healthcare, FMCG and realty stocks
MSCI's broadest index of Asia-Pacific shares outside Japan was little changed, but on track to end the week up 1.9 percent.
The dollar was generally weaker despite US shares gaining and the Dow Jones Industrial Average closing atop the 20,000 mark for the first time.
The Dow closed atop the 20,000 mark for the first time overnight as solid earnings and optimism over Mr Trump's pro-growth initiatives revitalised a post-election rally.
The index came within a point of the historic level on January 6, as investors banked on pro-growth policies and tax cuts from the new administration.
The dollar halted a three-day losing streak against a basket of its trade-weighted rivals and pushed higher on Tuesday, though it dipped again slightly on Wednesday.